synthesis, labeling, formulation and quality control of 99mtc-tricine-hynic-tyr³-octreotide, a peptide radiopharmaceutical for imaging somatostatin receptor positive tumors [persian]

somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. in this study tyr³-octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-boc-hydrazinopyridine-3-carboxylic acid (boc-hynic) and after deprotecting of conjugate, purification was performed with preparative-rp-hplc. the conjugated peptide was labeled with 99mtc and tricine as coligand. radiolabelling efficiency, radiochemical purity, stability in human serum, internalization of receptor bound 99mtc-labeled peptide and biodistribution in normal mice were studied.